Rick Sanchez is the co-eponymous main character and leading protagonist of the show.

Mortimer "Morty" Smith Sr. is one of the two eponymous main protagonists in Rick and Morty.

Jerry Smith is the ex-husband of Beth Smith and father to Summer Smith and, Morty Smith.

Beth Smith C-137 (n?e Sanchez) is the original version of Beth Smith, the daughter of Rick Sanchez, wife of Jerry Smith, and the mother of Morty and Summer Smith.

Summer Smith is the teenage daughter of Beth Smith, and Jerry Smith. She is the sister and granddaughter of her dimension's deceased Morty Smith and Rick Sanchez, respectively.